Drugs for Osteoarthritis
April 20, 2020 (Issue: 1596)
Many different drugs are used for treatment of
osteoarthritis pain, but none of them prevent
progression of the disease. Nonpharmacologic
approaches including weight management, exercise,
tai chi, physical therapy, assistive devices, and...more
- SL Kolasinski et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthrititis Rheumatol 2020; 72:220.
- S Wongrakpanich et al. A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging Dis 2018; 9:143.
- F Rannou et al. Efficacy and safety of topical NSAIDs in the management of osteoarthritis: evidence from real-life setting trials and surveys. Semin Arthritis Rheum 2016; 45(4 Suppl):S18.
- FKL Chan et al. Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. Lancet 2017; 389:2375.
- S Trelle et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 2011; 342:c7086.
- SE Nissen et al. Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis. N Engl J Med 2016; 375:2519.
- Celecoxib safety revisited. Med Lett Drugs Ther 2016; 58:159.
- Diclofenac gel for osteoarthritis. Med Lett Drugs Ther 2008; 50:31.
- DK Li et al. Use of nonsteroidal antiinflammatory drugs during pregnancy and the risk of miscarriage. Am J Obstet Gynecol 2018; 219:275.
- Inhibitors and inducers of CYP enzymes and P-glycoprotein. Med Lett Drugs Ther 2019 November 6 (epub). Available at: medicalletter.org/downloads/CYP_PGP_Tables.pdf.
- BR da Costa et al. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet 2017; 390:e21.
- In brief: does acetaminophen increase blood pressure? Med Lett Drugs Ther 2011; 53:29.
- Addendum: warfarin-acetaminophen interaction. Med Lett Drugs Ther 2008; 50:45.
- S Karami et al. Analgesic use and risk of renal cell carcinoma: a case-control, cohort and meta-analytic assessment. Int J Cancer 2016; 139:584.
- Z Liew et al. Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders. JAMA Pediatr 2014; 168:313.
- Y Ji et al. Association of cord plasma biomarkers of in utero acetaminophen exposure with risk of attention-deficit/hyperactivity disorder and autism spectrum disorder in childhood. JAMA Psychiatry 2020; 77:180.
- Duloxetine (Cymbalta) for chronic musculoskeletal pain. Med Lett Drugs Ther 2011; 53:33.
- ZY Wang et al. Efficacy and safety of duloxetine on osteoarthritis knee pain: a meta-analysis of randomized controlled trials. Pain Med 2015; 16:1373.
- JW Busse et al. Opioids for chronic noncancer pain: a systematic review and meta-analysis. JAMA 2018; 320:2448.
- Opioids for pain. Med Lett Drugs Ther 2018; 60:57.
- Another once-daily formulation of tramadol (Ryzolt). Med Lett Drugs Ther 2010; 52:39.
- C Gabay et al. Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center. Arthritis Rheum 2011; 63:3383.
- Turmeric supplements. Med Lett Drugs Ther 2019; 61:185.
- TE McAlindon et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage 2014; 22:363.
- RD Altman and HR Barthel. Topical therapies for osteoarthritis. Drugs 2011; 71:1259.
- Two new intra-articular injections for knee osteoarthritis. Med Lett Drugs Ther 2018; 60:142.
- GD Deyle et al. Physical therapy versus glucocorticoid injection for osteoarthritis of the knee. N Engl J Med 2020; 382:1420.
- TE McAlindon et al. Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial. JAMA 2017; 317:1967.
- AW Rutjes et al. Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med 2012; 157:180.
- Z Wang et al. Effectiveness of curcuma longa extract for the treatment of symptoms and effusion-synovitis of knee osteoarthritis: a randomized trial. Ann Intern Med 2020 September 15 (epub).
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